Professor of Cellular and Molecular Physiology; Director of Medical Studies; Director of Graduate Studies, Cellular and Molecular Physiology
Polarized kidney tubule cells have proteins in the plasma membrane facing the urine that differ from those facing the blood. We are studying the electrical characteristics of these proteins-ion channels and electrogenic transporters-in the two plasma membranes of renal tubule cells. Patchclamp, and molecular biology techniques are being used. 1.) We study the physiological role and regulation of single small-conductance chloride channels, CFTR, which are activated by cAMP through phosphorylation by protein kinase A. 2.) We study the ability of CFTR to function as a molecular gating switch for the renal potassium channel ROMK by regulating the ATP sensing of ROMK.
Dr. Boulpaep can be reached at email@example.com.